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SUMMARY:The CRISPR-Cas bacterial adaptive immune systems - Assoc. Prof. Pe
 ter Fineran\,  Department of Microbiology and Immunology\, University of O
 tago\, NZ.
DTSTART:20160801T120000Z
DTEND:20160801T133000Z
UID:TALK66904@talks.cam.ac.uk
CONTACT:Prof George Salmond
DESCRIPTION:Bacteria have evolved ‘immune systems’ as a result of thei
 r constant exposure to foreign mobile genetic elements\, including bacteri
 ophages and plasmids. For example\, an estimated 1025 bacteriophage infect
 ions occur every second\, which affects global nutrient cycles. Other mobi
 le genetic elements harbour antibiotic resistance or pathogenicity determi
 nants\, which influence bacterial evolution and our ability to treat infec
 tious disease. To thwart these invaders\, bacteria have many resistance st
 rategies\, including innate immunity\, such as restriction-modification an
 d abortive infection systems\, and adaptive immunity provided by the CRISP
 R-Cas systems. There have been major advances in our understanding of thes
 e systems recently. They have been exploited as molecular biology reagents
  and led to a new biotechnology revolution. I will present our recent rese
 arch into the function of the CRISPR-Cas adaptive immune systems in bacter
 ia. 
LOCATION:Department of Biochemistry\, Sanger Building Lecture Theatre
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