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SUMMARY:Evolution\, genomics and mode of action of long noncoding RNAs in 
 mammalian cells - Dr. Igor Ulitsky
DTSTART:20161019T150000Z
DTEND:20161019T160000Z
UID:TALK66990@talks.cam.ac.uk
CONTACT:46487
DESCRIPTION:We are interested in understanding the codes that drive the fu
 nctions of long noncoding RNAs (lncRNAs) in mammalian cells.  Comparative 
 analysis has played instrumental roles in allowing us to understand the ru
 les underlying protein and microRNA function\, but it has been difficult t
 o apply the existing methods to study lncRNAs because of scarcity of lncRN
 A annotations and rapid lncRNA evolution. To build a catalog of lncRNAs\ni
 n vertebrates\, we recently collected RNA-seq and 3P-seq data and develope
 d robust methods for lncRNA identification in 17 species (Hezroni et al.\,
  2015). We also developed methods for identifying lncRNA homologs based on
  subtle sequence homology and conservation of neighboring genes and genomi
 c context. We then focused on the evolutionary origins of those lncRNAs th
 at are found only in mammals and traced ~5% of them to protein-coding gene
 s that have lost their coding potential before the rise of mammals. These 
 pseudogene-derived lncRNAs are associated with features that set them apar
 t from other lncRNAs\, such as broader expression\ndomains. I will also de
 scribe our use experimental perturbations in human and mouse cells undergo
 ing differentiation to dissect lncRNA functions and the sequence and struc
 ture elements supporting them.\n
LOCATION:CRUK CI Room 215A/B
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