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SUMMARY:Bioluminescent Reporter Screens: Illuminating Novel Regulators and
  Dynamics of Signaling Pathways - Prof. David Piwnica-Worms. Department of
  Cancer Systems Imaging Deputy Division Head\, Research Affairs\, Division
  of Diagnostic Imaging Gerald Dewey Dodd\, Jr.\, Endowed Distinguished Cha
 ir in Diagnostic Imaging The University of Texas M.D. Anderson Cancer C
DTSTART:20161118T160000Z
DTEND:20161118T170000Z
UID:TALK67247@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:Bioluminescent imaging (BLI) is a powerful noninvasive tool th
 at has dramatically accelerated the in vivo interrogation of cancer system
 s and longitudinal analysis of mouse models of cancer over the past decade
 . Various luciferase enzymes have been genetically engineered into cells a
 nd mouse models of cancer\, which permit investigation of cellular and mol
 ecular events associated with oncogenic transcription\, posttranslational 
 processing\, protein–protein interactions\, transformation\, and oncogen
 e addiction in live cells and animals. Luciferase-coupled reporters ultima
 tely serve as a noninvasive\, repetitive\, longitudinal\, and physiologic 
 means by which cancer systems and therapeutic responses can be investigate
 d accurately within the context of a living animal.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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