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SUMMARY:Vesicle bionanotechnology and biophysics: from hybrid lipid-copoly
 mer systems to anticancer peptides - Prof. Paul Beales. School of Chemistr
 y\, University of Leeds\,
DTSTART:20161104T160000Z
DTEND:20161104T170000Z
UID:TALK67248@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:Natural phospholipids and synthetic block copolymers can both 
 spontaneous self-assembly in aqueous environments to form membranes\, whic
 h wrap into continuous spherical shells called vesicles. These vesicles ha
 ve wide-ranging uses in industry and academia ranging from fundamental bio
 physical studies of model biomembranes through to drug formulation and del
 ivery\, biosensors and development of artificial cells for synthetic biolo
 gy. I will present two recent projects from my group that span these appli
 cations. Firstly\, I will present our work on hybrid vesicles composed of 
 a blend of lipids and amphiphilic block copolymers. These vesicles aim to 
 synergistically combine the biofunctionality of liposomes with the stabili
 ty of polymersomes to create capsules with enhanced properties compared to
  the unitary systems. Significant disparity between the structure and prop
 erties of membranes formed by lipids and block copolymers make the materia
 l properties of these mixtures non-trivial. Secondly\, I will present a fu
 ndamental study of the membrane interactions of a wasp venom peptide in or
 der to uncover the mechanism behind its apparent anticancer properties.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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