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SUMMARY:“Lab on chip” – microfluidics\, organ on chip and biomimetic
  channel networks - Prof. Andreas Manz. Head of Research Korea Institute o
 f Science and Technology (KIST) Universität des Saarlandes. Saarbruecken\
 , Germany
DTSTART:20161021T150000Z
DTEND:20161021T160000Z
UID:TALK67249@talks.cam.ac.uk
CONTACT:Dr. Hernandez-Ainsa
DESCRIPTION:The idea to shrink a laboratory down to chip size\, or at leas
 t to integrate some critical lab tasks onto micro devices has been around 
 since over 20 years now. Some of my best years in „lab on a chip“ rese
 arch have been 1988-95 in Basel\, at Ciba-Geigy in Michael Widmer’s rese
 arch lab. In the meantime\, the field has grown significantly\, many of my
  students are now professors in this field\, the early patents are all exp
 ired\, small companies use microfluidics for their products\, and the main
  application focus has shifted from analytical chemistry to cell biology a
 nd tissue engineering [1].\n\nMicrofluidic chips are usually defined by ph
 otolithography masks which are generated from straight lines and CAD progr
 ams. The manufacturing process usually gets more complex if multiple depth
 s\, i.e. multiple masks have to be used\, and variations in depth profile 
 are difficult to achieve. I will present a simple way of obtaining channel
  structures which feature gradually increasing or decreasing channel depth
 s\, and which also can feature irregularities in its surface. At first sig
 ht\, this may seem inappropriate\, may look “ugly” and not engineering
 -like. However\, in biological surroundings\, we can see such structures\,
  and they are fully functional.\n\nPlant leaves are used as templates for 
 channel patterns\, including its fine structure and including its macrosco
 pic network pattern. Structures are formed in PDMS and covered by glass sl
 ides for microscopic observation [2]. Structures are used for investigatin
 g cell behaviour.\n\n\n[1] P Neužil\, S Giselbrecht\, K Länge\, TJ Huang
 \, A Manz\, “Revisiting lab-on-a-chip technology for drug discovery”\,
  Nature Reviews Drug Discovery 11 (8)\, 620-632 (2012).\n[2] W.Wu\, R.M.Gu
 ijt\, Y.E.Silina\, M.Koch\, A.Manz\, “Plant leaves as templates for soft
  lithography”\, RSC Advances 6\, 22469-22475 (2016)
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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