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SUMMARY:Mechanisms regulating tumor heterogeneity - Dr Cedric Blanpain (Un
 iversité Libre de Bruxelles\, Belgium)
DTSTART:20160929T120000Z
DTEND:20160929T130000Z
UID:TALK67290@talks.cam.ac.uk
CONTACT:Neil Bennett
DESCRIPTION:Different theories have been proposed to explain tumour hetero
 geneity including the cancer cell of origin.  Here\, we developed genetica
 lly engineered mouse models allowing lineage tracing together with oncogen
 ic activation in different cell lineages of the skin epidermis and the mam
 mary gland and assessed whether the cancer cell of origin controls tumour 
 heterogeneity. I will discuss evidence that the cancer cell of origin cont
 rols tumour heterogeneity and the underlying molecular mechanisms that pro
 mote tumor differentiation\, propagation\, EMT and metastasis in primary t
 umors. These results have important implications for our understanding of 
 the mechanisms controlling tumor heterogeneity and the development of new 
 strategies to block tumor initiation.\nThis work is supported by the ERC\,
  WELBIO\, the FNRS\, the Fondation Bettencourt-Schuler and the Fondation B
 aillet-Latour
LOCATION:CRUK CI Lecture Theatre
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