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SUMMARY:Active DNA demethylation and epigenetic anti-silencing in plants -
  Jian-Kang Zhu
DTSTART:20160905T130000Z
DTEND:20160905T160000Z
UID:TALK67339@talks.cam.ac.uk
CONTACT:Helen Scott
DESCRIPTION:In eukaryotic organisms\, numerous transposons and other repet
 itive sequences are subjected to DNA methylation-mediated transcriptional 
 silencing in order to maintain genome stability.  On the other hand\, some
  repetitive sequences including repetitive genes and genes with repeat ele
 ments need to be protected from epigenetic silencing in order to be expres
 sed.  The ROS1 subfamily of 5-methylcytosine DNA glycosylases/lyases funct
 ions to prevent transcriptional gene silencing in Arabidopsis by active DN
 A demethylation.  Our recent forward genetic screens have identified sever
 al proteins such as the histone acetyltransferase IDM1\, the alpha-crystal
 lin domain-containing proteins IDM2 and IDM3\, and the methyl-DNA-binding 
 protein MBD7\, that are required for ROS1 to demethylate some genomic loci
  including repetitive genes and genes containing repeat elements and to pr
 otect them from transcriptional silencing.  Our results suggest that these
  proteins form a protein complex that helps to recognize ROS1 target loci 
 and create a permissible chromatin environment for ROS1 to demethylate the
  target DNA.
LOCATION:Large Lecture Theatre\, Department of Plant Sciences
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