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SUMMARY:Structure and Function of TIFA - A New Player in Immunity and Canc
 er - Prof Ming-Daw Tsai (Academia Sinica in Taiwan)
DTSTART:20161010T140000Z
DTEND:20161010T150000Z
UID:TALK67419@talks.cam.ac.uk
CONTACT:Mairi Kilkenny
DESCRIPTION:TRAF-interacting protein with FHA domain (TIFA) was first repo
 rted by M. Kanamori et al. to activate NF-κB\, and it was recently shown 
 to be a key player in the NF-κB-driven innate immunity. In this seminar I
  will discuss our recent reports on the mechanism and structural basis for
  the function of TIFA in the activation of NF-κB\, as well as unpublished
  results suggesting that TIFA functionally mediates the Aurora A-driven NF
 -κB survival pathway in acute myeloid leukemia (AML)\, and that TIFA medi
 ates innate immune response through assembly of NLRP3 inflammasome.
LOCATION:Biochemistry Seminar Room\, Sanger Building
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