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SUMMARY:Overcoming Chromatin Barriers to Elicit Cell Fate Changes - Ken Za
 ret\, Joseph Leidy Professor\, Perelman School of Medicine\, University of
  Pennsylvania
DTSTART:20170119T130000Z
DTEND:20170119T140000Z
UID:TALK67459@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Cell fate changes involve dramatic and discrete switches in ge
 ne expression programs.  Such changes are initiated by pioneer transcripti
 on factors\, which can access nucleosomal DNA in silent chromatin that is 
 unmarked for activation or repression.  I will discuss how a segment of th
 e FoxA1 pioneer factor helps open such chromatin.  Yet there remain hetero
 chromatic regions of the genome that are difficult for nearly all regulato
 ry factors to access\, and which harbor genes required for terminal differ
 entiation.  I will discuss our discovery of diverse proteins that are embe
 dded in heterochromatin\, to understand how heterochromatin barriers can b
 e overcome in a specific fashion and promote high-fidelity cell fate chang
 es.  We find that marked dynamics in heterochromatin occur during organoge
 nesis\, which may focus regulatory factor access to the genome during the 
 period of rapid differentiation and growth.
LOCATION:CRUK CI Lecture Theatre
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