BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:"\;Negative-feedback control of cortical activity by the neuro modulator adenosine"\; PLEASE NOTE NEW DATE - Magnus Richardson\, Univ ersity of Warwick DTSTART:20161205T163000Z DTEND:20161205T180000Z UID:TALK67479@talks.cam.ac.uk CONTACT:Lyn Dakin DESCRIPTION:\nFast activity in neuronal networks is strongly affected by a variety of slowly acting neuromodulators. One such neuromodulator\, adeno sine\, is known to have a suppressive effect on cells and synapses in the cortex. Its transport in tissue and action on neocortical pyramidal cells and their connections is the focus of this talk. The complex dynamics of d iffusive signalling molecules in tissue is relatively poorly understood an d has been somewhat neglected by the main thrust of computational neurosci ence\, in part because extracellular concentrations are difficult to quant ify experimentally. Here recent work will first be presented on modelling the adenosine waveform\, the biophysics of its measurement using microelec trode biosensors and the spatial extent of the adenosine signal in tissue. The effects of adenosine on certain cellular and synaptic components of t he neocortex will then be examined. An unexpected connection will be shown between local adenosine concentrations and the development of short-term synaptic plasticity in the maturing neocortex that suggests a novel form o f long-term plasticity. The work presented is in collaboration with Dr Mar k Wall of the Warwick School of Life Sciences.\n\n LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo pment and Neuroscience END:VEVENT END:VCALENDAR