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SUMMARY:Dangerous Liaisons between platelets and cancer - Anil Sood\, MD -
  University of Texas\, MD Anderson Cancer Centre
DTSTART:20171214T130000Z
DTEND:20171214T140000Z
UID:TALK67497@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Platelets are well known to serve as “first responders” du
 ring normal wounding and homeostasis. However\, it is becoming increasing 
 clear that these anucleate platelets can influence several pathological pr
 ocesses including cancer. Tumor derived factors can drive megakaryopoiesis
 \, resulting in paraneoplastic thrombocytosis. Additionally\, thrombocytos
 is in cancer patients is associated with adverse patient survival. Experim
 ental evidence has highlighted the roles of platelets as important and act
 ive factors in many steps of tumorigenesis including tumor growth\, extrav
 asation of tumor cells and metastasis. Platelets can infiltrate into the t
 umor microenvironment to increase proliferation and inhibit apoptosis of c
 ancer cells. By secretion of large amounts of microparticles and exosomes\
 , platelets are well positioned to coordinate both local and distant tumor
 -host crosstalk. In this presentation\, I will present recent discoveries 
 related to the role of platelets in cancer progression. 
LOCATION:CRUK CI Lecture Theatre
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