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SUMMARY:RSC Prizewinner's seminar: Self-assembed coordination cages: host-
 guest chemistry and functional behaviour  - Prof. Michael Ward\, Universit
 y of Sheffield
DTSTART:20170316T140000Z
DTEND:20170316T150000Z
UID:TALK67504@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:Simple bis-bidentate bridging ligands based on two chelating p
 yrazolyl-pyridine termini combine with transition metal dications to give 
 a range of polyhedral coordination cages\, varying from M4L6 tetrahedra to
  M16L24 truncated capped tetrahedra\, with a metal ion at each vertex and 
 a bridging ligand spanning every edge.  Amongst these a set of M8L12 cubic
  cages have well-developed host-guest chemistry\, able to accommodate a wi
 de range of small molecules in the central cavity\, with binding constants
  of up to 10E8 M-1 in water.  Guest binding leads to a wide range of inter
 esting types of behaviour\, including (i) reversible uptake and release of
  drug molecules triggered by changes in pH\; (ii) luminescence signaling o
 f binding of chemical warfare agent simulants\; and (iii) substantial cata
 lytic acceleration with multiple turnovers of a range of reactions of boun
 d guests.
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry
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