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SUMMARY:Directing and shaping the inside-out axis of the vertebrate brain 
 - Professor Jon Clarke\, Department of Developmental Neurobiology\, King's
  College London 
DTSTART:20161020T130000Z
DTEND:20161020T140000Z
UID:TALK67535@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:We are attempting to understand the developmental mechanisms t
 hat drive organ and cell morphogenesis in the vertebrate embryo central ne
 rvous system. The fundamental building block of the embryonic vertebrate b
 rain is the neural tube which is an epithelium composed of apicobasally po
 larized neural progenitors. The polarity of these cells is essential for m
 any of the key events in building a brain but how this polarity is establi
 shed is poorly understood. We use the accessibility and transparency of th
 e zebrafish embryo to better understand neuroepithelial polarity and morph
 ogenesis\, and we are currently focused on  the role of cell division-depe
 ndent and division-independent processes\, directional signals from the EC
 M and the potential role of biomechanical forces.\n
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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