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SUMMARY:Using experimental evolution to understand adaptation from standin
 g genetic variation. - Professor Christian Schlotterer\, Institute of Popu
 lation Genetics of Vetmeduni Vienna 
DTSTART:20161027T130000Z
DTEND:20161027T140000Z
UID:TALK67536@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Experimental evolution in combination with whole genome sequen
 cing offers the unique opportunity to study adaptive processes under contr
 olled\, replicated conditions. Modifying the experimental protocol in comb
 ination with time series data\, we obtain very localized selection signatu
 res in D. simulans populations adapting to a new temperature regime. Combi
 ning genomic signatures with expression analyses we study two different ev
 olutionary processes and link them to natural populations. First\, we anal
 yze the metabolic rewiring during adaptation in the laboratory. We identif
 y AMPK\, a central metabolic switch\, as a key player in the laboratory. L
 inking the experimental evolution results to clinal variation in natural p
 opulations\, we show that AMPK is not only among the genes with the larges
 t clinal variation\, but populations from the extreme ends of the cline di
 ffer also in their expression pattern. As a second evolutionary process we
  study the invasion of the P-element into D. simulans. We show that the sp
 eed of the P-element invasion is triggered by temperature-specific express
 ion of the P-element. In the hot environment\, the spread of the P-element
  is already completed after about 20 generations. We show that at this tim
 e point piRNA-meditated defense has been established\, which are prevents 
 a further increase in P-element copy number. Hence\, similar to natural po
 pulations the P-element spread is controlled by piRNAs. 
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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