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SUMMARY:Defining transcription units across the human genome. - Professor 
 Nick Proudfoot\, Sir William Dunn School of Pathology\, University of Oxfo
 rd 
DTSTART:20161103T140000Z
DTEND:20161103T150000Z
UID:TALK67537@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:The dramatic achievement of sequencing the whole human genome 
 has been tempered by the subsequent realisation that the human transcripto
 me is far more complex than initially anticipated\; far from any clear und
 erstanding of how and why it is made. My lab has focused on the basic mech
 anism of transcriptional termination and associated RNA 3’ end processin
 g by the major RNA polymerase II (Pol II) that is responsible for the synt
 hesis of all pre messenger RNA and most non coding RNAs. We have uncovered
  a surprising diversity of termination mechanisms using gene specific anal
 yses. We are now applying new native elongating transcription (NET) sequen
 cing strategies to define all Pol II transcription units (especially mamma
 lian NET-seq). Using this technology we are uncovering unanticipated mecha
 nistic cross talk between the basic transcription process and associated p
 re-mRNA and long non coding RNA processing.\n\n
LOCATION:Biffen Lecture Theatre\, Department of Genetics\, Downing Site
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