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SUMMARY:Genomic Approaches to Cancer  - Todd Golub\, Broad Institute of MI
 T and Harvard\, Dana-Farber Cancer Institute
DTSTART:20171116T130000Z
DTEND:20171116T140000Z
UID:TALK67648@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:It is now becoming possible to bring powerful genomic methods 
 to bear on the process of cancer drug discovery. This talk will illustrate
  1) the use of the Connectivity Map\, a large-scale effort to develop a co
 mpendium of gene expression signatures of cellular state\, 2) the use of P
 RISM\, a new multiplexed\, high throughput approach to screening cancer ce
 ll lines for anti-cancer activity and resistance\, and 3) the use of cance
 r models (cell lines and patient-derived xenografts) in discovery\, with p
 articular focus on clonal drift in these models and the impact of that dri
 ft on drug sensitivity.
LOCATION:CRUK CI Lecture Theatre
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