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SUMMARY:Synthesis and Analysis of Nanobody Sequence and Structure Data - L
 aura Mitchell (University of Cambridge)
DTSTART:20161028T110000Z
DTEND:20161028T112000Z
UID:TALK68025@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Nanobodies are a class of antigen-binding protein derived from
  heavy-chain antibodies in camels\, llamas and alpacas. They achieve high 
 affinity binding specificities equivalent to antibodies\; despite comprisi
 ng only a single 15 kDa variable domain. Their restricted size greatly red
 uces the possible sequence space available for encoding specificity\, maki
 ng the question underpinning the sequence-specificity relationship more tr
 actable. In this talk I present sequence and structural analysis of the la
 rgest set of nanobody:antigen co-crystal structures compiled to date\, whi
 ch has revealed surprising findings relating to the conservation of nanobo
 dy framework regions\, the composition of nanobody sequence-variable loops
  and the distribution of specificity-determining residues.
LOCATION:Unilever Lecture Theatre\,  Department of Chemistry
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