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SUMMARY:Insights into compound mode-of-action by exploring gene expression
  space - Benjamin Alexander-Dann (University of Cambridge)
DTSTART:20161118T120000Z
DTEND:20161118T122000Z
UID:TALK68035@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:Recent innovation in transcriptomics have led to large amounts
  of specific compound-induced gene expression data being made available in
  the public domain. This data is noisy and often difficult to interpret. I
 ntegrating this space with other spaces\, including chemical bioactivity\,
  pathway and various compound annotations\, provide insight into the mode-
 of-action of small molecules. Furthermore\, this aids the drug development
  pipeline and may provide opportunities for drug repurposing.  In this tal
 k I shall outline the basis of compound-induced gene expression profiles a
 nd various methods to integrate this data towards obtaining clinically rel
 evant inferences.
LOCATION:Unilever Lecture Theatre\,  Department of Chemistry
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