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SUMMARY:The causes and consequences of cellular circadian rhythms - Dr Joh
 n O'Neill\, University of Cambridge
DTSTART:20161006T150000Z
DTEND:20161006T160000Z
UID:TALK68334@talks.cam.ac.uk
CONTACT:Maria Schacker
DESCRIPTION:Circadian (approximately daily) rhythms are cell-autonomous os
 cillations that permeate every level of biology\, and thereby impact upon 
 many aspects of health and disease. In humans for example\, our sleep/wake
  cycle has a clear circadian rhythm\; whereas clock disruption\, as occurs
  during shift work\, is strongly associated with conditions such metabolic
  syndrome\, cardiovascular disease and various cancers. Current evidence s
 uggests that whilst cycles of nascent 'clock gene' expression are required
  for daily rhythms in behaviour and physiology\, they are insufficient to 
 explain circadian timekeeping at the cellular level. Our current research 
 is focused on understanding the cellular clock mechanism and how it facili
 tates temporal regulation of biological function. I will talk about the wa
 y in which circadian rhythms of actin cytoskeletal dynamics regulate fibro
 blast motility during wound healing\, as well as an evolutionarily conserv
 ed rhythm in cellular magnesium transport\, as examples of our recent work
 .
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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