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SUMMARY:Polymer Physics and DNA Topology - Professor Giovanni Dietler\, La
 boratoire de Physique de la Matière Vivante\, Institut de Physique de la 
 Matiere Complexe\n\, Ecole Polytechnique Fédérale de Lausanne\, Switzerl
 and
DTSTART:20070427T131500Z
DTEND:20070427T141500Z
UID:TALK6852@talks.cam.ac.uk
CONTACT:Jurij Kotar
DESCRIPTION:DNA appears in linear\, circular and knotted forms\, depending
  on the situation and conditions. It is therefore an excellent playground 
 for polymer physics to test theoretical concepts. In the present lecture\,
  I will first focus on the properties of linear DNA and show that critical
  exponents describing the divergence of the end-to-end distance can be det
 ermined from Atomic Force Microscopy images of DNA and that the end-to-end
  distance distribution as a function of the DNA length can also be determi
 ned. Then\, the properties of knotted DNA in respect to the critical expon
 ents and the localization of the knot crossings will be reported: I will s
 how that probably two universality classes exist in this case and that loc
 alization of the knot crossings could explain the activity of the topoisom
 erases. At the end of the lecture\, gel electrophoresis of DNA knots will 
 be discussed and simulation as well as experiments will be presented where
  the knot complexity and its toopology play an essential role.
LOCATION:IRC in Superconductivity Seminar Room\, Cavendish Laboratory
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