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SUMMARY:Looking beyond luminal stenosis: Atherosclerosis Imaging and Biome
 chanical Analysis - Dr Zhongzhao Teng (Cambridge Neuroscience)
DTSTART:20161107T140000Z
DTEND:20161107T150000Z
UID:TALK68864@talks.cam.ac.uk
CONTACT:48368
DESCRIPTION:Most strokes and heart attack are due to the rupture of an ath
 erosclerotic plaque. Plaque compositional features depicted by in vivo ima
 ging including high resolution MRI and VH-IVUS have been shown to provide 
 complementary value to luminal stenosis in identifying higher-risk lesions
 . However\, the predicting power is still low and additional biomarkers ar
 e needed. Under the physiological condition\, plaque is subject to mechani
 cal loading due to pulsatile blood pressure and flow. Plaque structure pos
 sibly fails if this loading exceeds its material strength. Therefore\, cri
 tical mechanical conditions should be integrated with plaque compositional
  features for a more accurate vulnerability assessment. This talk will ove
 rview recent advancements in mechanics-based plaque vulnerability assessme
 nt\, highlight current challenging and propose strategies that how this no
 vel technique should be integrated with in vivo imaging for a refined risk
  stratification.
LOCATION:MR14\, Centre for Mathematical Sciences
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