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SUMMARY:Circuits principles of memory-based behavioral choice - Marta Zlat
 ic (None / Other)
DTSTART:20161110T100000Z
DTEND:20161110T110000Z
UID:TALK68920@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:<span>Choosing which behavior to generate based on sensory inp
 uts and previous experience is crucial for survival. To understand the cir
 cuit principles by which experience-driven behavioral choices are made it 
 is essential to determine the architecture of networks that mediate these 
 functions\, and determine the causal relationships between the structural 
 motifs and function. We combine three levels of analysis: i) circuit mappi
 ng with synaptic resolution\; ii) physiological measurements of neural act
 ivity and iii) neural manipulation in freely behaving animals to dissect t
 he logic of memory-based behavioral choice in <i>Drosophila</i> larva. In 
 an EM volume that spans the entire nervous system we reconstructed a compl
 ete wiring diagram of the higher order parallel fiber system for associati
 ve learning\, the Mushroom Body (MB)\, including the pathways from the con
 ditioned (CS) and unconditioned sensory (US) neurons to the MB\, and the p
 atterns of interactions of MB output neurons with circuits that mediate in
 nate responses to CS and US. Using calcium imaging and optogenetic manipul
 ation of individual MB input and output neurons we elucidated the logic of
  punishment and reward encoding by the ensemble of dopaminergic MB input n
 eurons and the logic by which the MB interacts with pathways for innate re
 sponses to olfactory stimuli in the larva brain\, the Lateral Horn (LH). I
  will discuss key findings from these studies. </span>  <br><br><br><br>
LOCATION:Seminar Room 2\, Newton Institute
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