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SUMMARY:Membrane curvature\, a non-stochastic regulator of protein localiz
 ation\, structure and function - Dimitrios Stamou
DTSTART:20161102T103000Z
DTEND:20161102T113000Z
UID:TALK68934@talks.cam.ac.uk
CONTACT:Francesco Simone Ruggeri
DESCRIPTION:To date we have established exhaustive correlations between th
 e lipid composition of membranes and its impact on membrane properties and
  protein function. In addition to composition the shape of cellular membra
 nes appears to be a well-conserved phenotype in evolution. Nevertheless we
  largely ignore what are the consequences of membrane shape/curvature to b
 iological functions that make it so critical for sustaining life. Here I w
 ill discuss published and unpublished data from in vitro and living cell e
 xperiments on several important classes of biomolecules whose localization
 \, structure or function exhibited dramatic curvature dependence including
  i) GPCRs and ii) membrane anchored proteins like Ras.
LOCATION:Department of Chemistry\, Unilever Lecture Theatre
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