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SUMMARY:Genome architecture and chromatin regulation in C. elegans - Profe
 ssor Julie Ahringer\, The Gurdon Institute
DTSTART:20161102T140000Z
DTEND:20161102T150000Z
UID:TALK68959@talks.cam.ac.uk
CONTACT:Emily Boyd
DESCRIPTION:All nuclear events take place in the context of chromatin\, th
 e organization of genomic DNA with histones and hundreds of associated pro
 teins and RNAs. Regulating the composition and structure of chromatin cont
 rols transcription and other nuclear processes\, and is important for cell
  fate decisions\, the expression of cell identity\, the maintenance of plu
 ripotency\, and the transformation to cancer.  We use C. elegans to study 
 chromatin regulation in gene expression and genome organization in a whole
  organismal context\, because it has a complement of core chromatin factor
 s very similar to that of humans\, a small well-annotated genome (30x smal
 ler than human)\, RNAi for loss of function studies\, and well-characteris
 ed cell fates. I will discuss our work on the properties and activities of
  promoters and enhancers\, the regulation and function of chromatin domain
 s\, and interactions between regulatory elements.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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