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SUMMARY:Halocarbons in Nanomedicine and Nanotechnology: New opportunities 
 and challenges - Pierangelo Metrangolo\, Politecnico di Milano
DTSTART:20170131T160000Z
DTEND:20170131T170000Z
UID:TALK68992@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:The lecture is divided into three different but interwoven top
 ics. First\, it will be shown how halocarbons are useful supramolecular bu
 ilding blocks. In particular\, the halogen bond\, namely the noncovalent i
 nteraction involving halogen atoms as electrophilic species drives the int
 ermolecular recognition and self-assembly of halocarbons with anions\, pol
 ymers\, and proteins allowing for the obtainment of an entirely new class 
 of functional materials displaying unique features. Photoresponsive materi
 als\, super hydrogelators\, porous templates\, among others\, were obtaine
 d. On the other hand halocarbons are also widespread pollutants which func
 tion as endocrine disruptors\, biomimicking thyroid hormone mechanism of a
 ction. For this reason\, we engineered monoclonal antibodies that by mimic
 king thyroxine binding are able to selectively recognize tetrahalogenated 
 bisphenols\, which are a class of industrial pollutants of recent concern 
 for public safety. Halogenation of protein is also a well-known oxidative 
 stress-related mechanism\, which plays a role in many diseases\, such as P
 arkinson’s\, cystic fibrosis\, asthma\, allergies\, etc. We have propose
 d for the first time that halogenation may alter protein self-assembly and
  fibrillation as a consequence of unnatural halogen bonding. Finally\, it 
 will be shown how fluorinated molecules behave as powerful bioimaging cont
 rast agents\, and deliver new solutions in theranostics and nano medicine.
 \n\n1. Metrangolo\, P.\; et al. Chem. Rev. 2016\, 116\, 2478.\n2. Metrango
 lo\, P.\; et al. Nature Commun. 2014\, 5:4043\, DOI: 10.1038/ncomms5043.\n
 3. Metrangolo\, P.\; et al. Adv. Funct. Mater. 2012\, 22\, 2571.\n4. Metra
 ngolo\, P.\; et al. Nature Commun. 2015\, 6:7574\, DOI: 10.1038/ncomms8574
 .\n5. Metrangolo\, P.\; et al. Science 2009\, 321\, 918.\n6. Metrangolo\, 
 P.\; et al. Nature Chem. 2012\, 4\, 437.\n\nPierangelo Metrangolo is full 
 professor at Politecnico di Milano. He also holds a position as visiting p
 rofessor at VTT-Technical Research Centre of Finland and at the Centre of 
 Excellence in Molecular Engineering of Biosynthetic Hybrid Materials of Aa
 lto University\, Finland. His awards include the 2005 ‘‘G. Ciamician
 ’’ medal of the Division of Organic Chemistry of the Italian Chemical 
 Society and the 2005 Journals Grant Award of the Royal Society of Chemistr
 y. He is Co-Editor of Acta Crystallogr. B (IUCr)\, is in the editorial boa
 rd of CrystEngComm (RSC)\, and in the Editorial Advisory Board of Cryst. G
 rowth Des. (ACS). He is author of 191 publications with\n10138 citations (
 H-index: 51). He is currently Titular Member of the Physical and Biophysic
 al Chemistry Division of the IUPAC. Since 2013 he is European Research Cou
 ncil grantee with the project “FOLDHALO – Folding with Halogen Bonding
 ”\, aimed at investigating the relevance of biomolecular halogen bonds.
LOCATION:Pfizer LT
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