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SUMMARY:Polymers through protein pores: single-molecule experiments with n
 ucleic acids\, polypeptides and polysaccharides - Professor Hagan Bayley\,
  Department of Chemistry\, University of Oxford
DTSTART:20161109T103000Z
DTEND:20161109T113000Z
UID:TALK69046@talks.cam.ac.uk
CONTACT:23027
DESCRIPTION:When polymers move from one cellular compartment to another\, 
 they pass through protein pores. Nucleic acids\, polypeptides and polysacc
 harides are all transported in this way\, stimulating questions about the 
 nature of the transported polymer (diameter\, stiffness\, branching\, char
 ge\, charge distribution)\, the driving force (DV\, DpH\, refolding\, bind
 ing) and how that driving force is coupled (direct coupling v diffusion/ r
 atchet). We have been investigating all three classes of biopolymer by cur
 rent recording through individual transmembrane pores. We have not only ma
 de interesting fundamental discoveries about the translocation processes\,
  but also found useful applications of our work\, for example in nucleic a
 cid sequencing and the discovery of antibacterial agents.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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