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SUMMARY:Imaging the cytoskeleton – re-defining a biological entity with 
 fluorescent antibodies - Hanna Lucia Worliczek (University of Vienna)
DTSTART:20161201T130000Z
DTEND:20161201T140000Z
UID:TALK69187@talks.cam.ac.uk
CONTACT:Richard Staley
DESCRIPTION:This paper traces a substantial visual end epistemic change in
  cell biology research in the early 1970s\, initiated by the adoption of f
 luorescence microscopy\, using antibodies for labelling proteins\, from di
 agnostic research on viral and bacterial pathogens. With the first paper a
 pplying this method to cytoskeleton research\, published 1974 in the Proce
 edings of the National Academy of Sciences of the USA\, a new kind of visu
 al evidence got established in a field\, which until then was dominated by
  electron microscopy as the most important imaging technique. As I will sh
 ow\, the application and establishment of fluorescence microscopy not only
  re-defined the cytoskeleton as a biological entity of similar importance 
 as other already well-described organelles like the nucleus\, the Golgi ap
 paratus or the endoplasmic reticulum. It furthermore facilitated a new ico
 nography of the cell and a significant epistemic change: it was now possib
 le to stain proteins specifically in fixed cells\, allowing the visualizat
 ion of the molecular architecture of various cell components in situ. Base
 d on manuscripts\, published articles and textbooks\, editorial archives\,
  papers of the American Society for Cell Biology\, as well as interviews w
 ith researchers\, technology developers and editors\, I aim to reconstruct
  and understand how a new kind of image could be established as central ev
 idence for findings and hypotheses and how the associated visual knowledge
  shaped the field of cell biology.
LOCATION:Seminar Room 2\, Department of History and Philosophy of Science
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