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SUMMARY:Complement therapeutics on the crossroads between inflammatory and
  infectious disease - Professor Wilhelm Schwaeble\, Professor of Immunolog
 y\, University of Leicester
DTSTART:20170111T160000Z
DTEND:20170111T170000Z
UID:TALK69239@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:The complement system contributes critically to an effective i
 mmune response and maintains the body's integrity by facilitating the remo
 val of debris\, aggregates of immunoglobulins\, and targeted microbial org
 anisms and cells. \n\nThis elimination of debris\, microbial organisms\, v
 iruses\, cell fragments and toxins is achieved by stimulating their enhanc
 ed uptake and removal by phagocytic cells.\n\nIn addition to its scavenger
  function\, complement can kill certain bacteria and directly lyse suscept
 ible cells through the formation of membrane attack complexes. Complement 
 activation products can also direct phagocytes to the infected areas of th
 e body and drive immune cells into a stage of high alert to mount an infla
 mmatory response.\n\nWhile a compromised and ineffective complement system
  can dramatically increase susceptibility to infection\, overreacting and 
 insufficiently controlled complement activation can promote the transition
  from acute to chronic inflammation and inflammatory disease leading to th
 e loss of vital tissue and organ functions. For some disease conditions\, 
 the pathophysiological contributions of inefficiently controlled complemen
 t activation were identified decades ago. Modern gene association studies\
 , however\, revealed a much wider spectrum of disease conditions where com
 plement plays a pathophysiological key role. This underlined the need to d
 evelop specific therapeutic tools to treat complement driven pathologies a
 s a clinical priority.\n\nThis presentation will introduce the various pre
 sently pursued strategies to treat complement dependent disease and discus
 s and compare their specific benefits and possible side effects.\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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