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SUMMARY:Sensitivity to BST-2 restriction correlates with Orthobunyavirus h
 ost range. - Dr Mariana Varela\, Institute of Infection\, Immunity and Inf
 lammation\, University of Glasgow
DTSTART:20170222T160000Z
DTEND:20170222T170000Z
UID:TALK69466@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Orthobunyaviruses include several recently emerging viruses of
  significant medical and veterinary importance. There is currently very li
 mited understanding on what determines the host species range of these pat
 hogens. In this study we discovered that BST-2\, an interferon stimulated 
 gene also known as tetherin\, restricts orthobunyavirus replication in a h
 ost-specific manner. We show that viruses with human tropism (Oropouche vi
 rus and La Crosse virus) are restricted by sheep BST-2 but not by the huma
 n orthologue while viruses with ruminant tropism (Schmallenberg virus and 
 others) are restricted by human BST-2 but not by the sheep orthologue. Cac
 he valley virus\, an orthobunyavirus known to infect both sheep and humans
  is not restricted by either BST-2 orthologues. This is the first study id
 entifying a host determinant of species susceptibility to bunyavirus infec
 tion. This work provides critical insight to help us dissect the adaptive 
 changes that bunyaviruses require to cross the species barrier and emerge 
 into new species.
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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