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SUMMARY:Studies on the Molecular Recognition of aminoglycoside antibiotics
  by nucleic acids and proteins - Juan Luis Asensio\, Instituto de Química
  Orgánica General\, Madrid
DTSTART:20170315T160000Z
DTEND:20170315T170000Z
UID:TALK69506@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:Carbohydrates are involved in a large variety of molecular rec
 ognition processes of biological relevance\, involving both proteins and n
 ucleic acid receptors. Understanding how these later bio-molecules interac
 t with glycosides represents a fundamental issue in chemical biology with 
 far reaching implications in fundamental biology\, biotechnology or drug d
 esign. Aminoglycoside antibiotics constitute a paradigmatic example of bio
 logically active glycosides. These compounds\, widely used in clinics\, bi
 nd to a large variety of RNA/DNA fragments\, and\, consequently\, could be
  considered promising leads for the development of improved nucleic acid l
 igands. The description\, in recent years\, of several clinically relevant
  aminoglycoside/receptor complexes has greatly stimulated the structural-b
 ased design of new improved derivatives. Unfortunately\, design efforts ha
 ve frequently met a limited success\, reflecting our incomplete understand
 ing of the driving forces that promote complex formation. As a part of an 
 ongoing project oriented to the study of carbohydrate molecular recognitio
 n in biological environments we have analyzed several key aspects of the a
 minoglycoside binding to RNA and proteins\, employing a pluridisciplinar a
 pproach that includes NMR\, molecular modeling\, organic synthesis\, and d
 ifferent biophysical techniques. The obtained results\, together with alte
 rnative approaches for the design of improved aminoglycoside ligands\, wil
 l be discussed.\n\n1.-Jiménez-Moreno\, E.\; Montalvillo-Jiménez\, L.\; S
 antana\, A.G.\; Gómez\, A.M.\; Jiménez-Osés\, G.\; Corzana\, F.\; Basti
 da\, A.\; Jiménez-Barbero\, J.\; Cañada\, F.J.\; Gómez-Pinto\, I.\; Gon
 zález\, C.\; Asensio\, J.L.* J. Am. Chem. Soc. 2016\, 138\, 20\, 6463\n2.
 -Jiménez-Moreno\, E.\;  Jiménez-Osés\, G.\; Gómez\, A.M. Santana\, A.G
 .\; Corzana\, F.\; Bastida\, A.\; Jiménez-Barbero\, J.\; Asensio\, J.L.* 
 Chemical Science 2015\, 6\, 6076.\n3.-Jiménez-Moreno\, E.\; Gómez\, A.M.
 \;  Bastida\, A.\; Corzana\, F.\; Jiménez-Oses\, G.\; Jiménez-Barbero\, 
 J.\; Asensio\, J.L. * Angew. Chem. Int. Edit. 2015\, 54\, 4344.\n4.-Jimén
 ez-Moreno\, E.\; Gómez-Pinto\; I.\; Corzana\, F.\; Santana\, A.G.\; Revue
 lta\, J.\; Bastida\, A.\; Jiménez-Barbero\, J.\; González\, C.\; Asensio
 \, J.L.* Angew. Chem. Int. Edit. 2013\, 52\, 3148.\n5.-Santana\, A.G.\; Ji
 ménez-Moreno\;\, E.\; Gómez\, A.M.\; Corzana\, F.\; González\, C.\; Jim
 énez-Oses\, G.\; Jiménez-Barbero\, J.\; Asensio\, J.L.* J.  Am.  Chem. S
 oc. 2013\, 135\, 3347.\n6.-Vacas\, T.\; Corzana\, F.\;Jimenez-Oses\, G.\; 
 González\, C.\; Gomez\, A.M.\; Bastida\, A.\; Revuelta\, J.\; Asensio\, J
 .L.* J. Am. Chem. Soc. 2010 132\, 12074.
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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