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SUMMARY:The phage T4 DNA and protein packaging machine – Old\, New\, Wid
 ely true\, useful too - Professor Lindsay W. Black\, Department of Biochem
 istry and Molecular Biology\, University of Maryland\, Baltimore\, USA
DTSTART:20170117T143000Z
DTEND:20170117T150000Z
UID:TALK69677@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Viral genome packaging into capsids is powered by ATP driven h
 igh-force-generating motor proteins.  In vitro the phage T4TerL alone pack
 ages any linear DNA into portal containing proheads by “crunching”  it
  transiently from B- to A-form.  But In vivo we show that a twin ring form
  of T4 TerS is required to gauge DNA synthesis adequate for packaging by 
 “synapsing” two homologous pac sites. The Protein And Nucleic Acid Tar
 geting System Using T4 Phage (PANTSUP) viral nanocontainer can be used for
  highly efficient and specific transfer of active proteins and corrected s
 equence DNA into genetically-deficient cell lines.  Refs:PMID:25728298
LOCATION:Online
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