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SUMMARY:A novel role for phage P22’s scaffolding protein: triggering por
 tal ring oligomerization and incorporation during procapsid assembly - Dr.
  Tina Motwani\, University of Connecticut\, Storrs\, United States
DTSTART:20170117T160000Z
DTEND:20170117T163000Z
UID:TALK69679@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:The majority of DNA viruses package their genomes into preform
 ed precursor capsids through a portal protein complex incorporated in the 
 capsid at a single vertex. The existence of a unique portal complex is cru
 cial to the formation of mature infectious virions\, but how only one port
 al assembly is selectively incorporated at a special vertex is unclear. He
 re\, we show incorporation of bacteriophage P22 portal protein into PC in 
 vitro as pre-assembled dodecameric rings. A novel role for the scaffolding
  protein in triggering portal ring formation from portal monomers was also
  found. Thus\, new details are revealed about this critical step in the as
 sembly of icosahedral viruses that use a portal protein in conjunction wit
 h a genome-packaging motor to encapsulate their genetic material.
LOCATION:Online
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