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SUMMARY:Metabolic Reprogramming in Microgravity 3D Spheroids - Professor S
 tephen J. Fey\, Department of Biochemistry and Molecular Biology\, Univers
 ity of Southern Denmark\, Odense\, Denmark
DTSTART:20170207T080000Z
DTEND:20170207T083000Z
UID:TALK69740@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Microgravity spheroids reach a metabolic equilibrium after 18 
 days in culture and maintain this equilibrium for at least 24 days thereaf
 ter. Spheroids grown from HepG2/C3A cell line are large (ca. 0.8 - 1mm in 
 diameter)\, reproducible\, and show significant structural and ultrstructu
 ral similarities to human liver and differences compared to the same cells
  grown in the same conditions in classical tissue culture conditions. Most
  importantly\, they are highly tissue mimetic. They are more accurate than
  primary human hepatocytes for predictive toxicology. They recover epigene
 tic markings and histone clipping seen in vivo and they display clear meta
 bolic reprogramming.
LOCATION:Online
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