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SUMMARY:Gene Activated Matrices for Bone Regeneration - Professor Aliasger
  K. Salem\, College of Pharmacy\, University of Iowa\, 115 S. Grand Avenue
 \, Lowa City\, United States
DTSTART:20170208T143000Z
DTEND:20170208T150000Z
UID:TALK69751@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Gene therapy using non-viral vectors that are safe and efficie
 nt in transfecting target cells is an effective approach to overcome the s
 hortcomings of protein delivery of growth factors. The objective of our st
 udy was to develop and test a non-viral gene delivery system for bone rege
 neration utilizing a collagen scaffold to deliver polyethylenimine (PEI)-p
 lasmid DNA (pDNA) [encoding platelet derived growth factor-B (PDGF-B)] com
 plexes. In vivo studies showed significantly higher new bone volume/total 
 volume (BV/TV) % in calvarial defects treated with the complex-activated s
 caffolds following 4 weeks of implantation (14-and 44-fold higher) when co
 mpared to empty defects or empty scaffolds\, respectively.
LOCATION:Online
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