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SUMMARY:Engineering a Bio-Inspired Bone Marrow Biomicry: Applications to P
 recision Medicine - Professor Athanasios Mantalaris\, Imperial College Lon
 don\, London\, United Kingdom
DTSTART:20170209T083000Z
DTEND:20170209T090000Z
UID:TALK69753@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Professor Athanasios Mantalaris\, Imperial College London\, Lo
 ndon\, United Kingdom\nPersonalized medicine is a medical model that propo
 ses the customization of healthcare\, with decisions and practices being t
 ailored to the individual patient by use of patient-specific information (
 initially genetics information) and/or the application of patient-specific
  cell-based therapies. The BioBlood project aims to deliver personalised h
 ealthcare through a “step change” in the clinical field of haemato-onc
 ology. BioBlood represents an engineered bio-inspired integrated experimen
 tal/modelling platform for normal and abnormal haematopoiesis that receive
 s disease & patient input (patient primary cells & patient/disease-specifi
 c data) and will produce cellular (red blood cell product) and drug (optim
 al drug treatment) therapies as its output. Herein\, we will present the e
 xperimental platform\, which is a novel three-domensional hollow fibre bio
 reactor capable of culturing normal and abnormal haematopoietic cells in t
 he absence of exogenous growth factors by mimicking the structure and func
 tion of the bone marrow\, alongside a population balance model (PBM) that 
 is able to capture cellular heterogenity and in particular leukaemia heter
 ogenity. The PBM\, which is able to extract patient- and disease-specific 
 information is linked to a pharmacokinetic/pharmacodynamic (PD/PD) model\,
  which is the used to optimise chemotherapy treatment in a personalised ma
 nner.\n
LOCATION:Online
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