BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Beyond E/I balance: Inhibitory cell-type regulating circuit wide d
 efects in Rett syndrome  - Dr Abhishek Banerjee - Brain Research Institute
 \, University of Zürich
DTSTART:20170123T130000Z
DTEND:20170123T140000Z
UID:TALK69811@talks.cam.ac.uk
CONTACT:Lorraine Coulson
DESCRIPTION:​Over the years\, balance of excitation and inhibition (E/I)
  have provided a simplistic view of synaptic computation and its alteratio
 n in neurological disorders. Recent advances in understanding neural circu
 its that processes sensory information have revealed that even during norm
 al physiological function\, magnitude and direction of changes in excitati
 on and inhibition is extremely dynamic to support ongoing circuit computat
 ion. In this talk\, I will present evidences from Rett syndrome (RTT)\, a 
 neurological disorder arising from loss of function mutations in Mecp2\, h
 ow the functional effects of MeCP2 in inhibitory interneuron subtypes crit
 ically control visual information processing by non-cell autonomously affe
 cting target cell response specificity and selectivity. Mecp2 deletion als
 o alters cellular Cl- balance further impacting effectiveness of early inh
 ibition. Administration of human recombinant IGF-1 (rhIGF1)\, a drug in Ph
 ase-II clinical trial\, cell-type specifically restores cellular and circu
 it defects. Thus\, loss of MeCP2 from specific interneuron types contribut
 es crucially to the cell-specific and circuit-wide deficits in RTT\, sugge
 sting that targeting such neurons will offer a mechanism-based therapeutic
  role for rhIGF1 in treating RTT.​ ​Finally\, I will discuss new appro
 aches using awake behaving animals to study defects in learning dynamics i
 n neurological disorders. 
LOCATION:Kenneth Craik Room\, Craik Marshall Building\, Downing Site\, Cam
 bridge
END:VEVENT
END:VCALENDAR