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SUMMARY:Cellular adhesion during cellular senescence and ageing - Dr. Ana 
 O'Loghlen\, Queen Mary University of London\, London\, United Kingdom
DTSTART:20170222T083000Z
DTEND:20170222T090000Z
UID:TALK69820@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Cellular senescence is an important in vivo mechanism that pre
 vents the propagation of damaged cells. Senescent cells undergo extensive 
 metabolic and transcriptional changes\, affecting their surrounding microe
 nvironment. Activation of senescence during aging has been demonstrated to
  be detrimental. However\, the precise mechanism(s) regulating senescence 
 and aging and how senescence influences the tissue homeostasis is not well
  characterized. Here\, we show a role for integrin beta 3 (β3) as a hallm
 ark of cellular senescence and aging. β3 expression accelerates the onset
  of senescence in human primary fibroblasts by activating the TGFβ pathwa
 y. ITGB3 is transcriptionally regulated during oncogene-induced senescence
  (OIS)\, causing an increase in the endogenous levels β3. Conversely\, pe
 rturbation of β3 levels or activity overrides OIS. Finally\, we show an i
 ncrease in β3 levels during aging in mice and humans. Altogether\, these 
 results show a role for the integrin subunit\, β3\, during senescence.
LOCATION:Online
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