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SUMMARY:Interventions in Accelerated Aging - Dr. Morten Scheibye-Knudsen\,
  National Institute of Health\, Bethesda\, United States
DTSTART:20170223T143000Z
DTEND:20170223T150000Z
UID:TALK69830@talks.cam.ac.uk
CONTACT:Ilana Spilka
DESCRIPTION:Accelerated aging disorders represent a phenotypically diverse
  group of diseases all with defects in DNA maintenance. In a subset of the
 se disorders\, neurodegeneration is prominent.  Notably\, the neurological
  phenotype is strikingly similar to what is seen in primary mitochondrial 
 disorders\, an observation that we have investigated and corroborated usin
 g in silico\, in vitro and in vivo methods. The mitochondrial dysfunction 
 in these neurodegenerative diseases may be caused by hyperactivation of a 
 nuclear DNA damage response involving the enzyme poly-ADP-ribose-polymeras
 e 1 (PARP1) leading to loss of NAD and alterations in cellular and organis
 mal metabolism. Interventions at steps in this pathway lead to normalizati
 on of the mitochondrial phenotypes suggesting that new treatments may be p
 ossible for these\, previously\, untreatable disorders.
LOCATION:Online
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