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SUMMARY:Development and Production of Nuclear Probes for Molecular Imaging
  in-vivo - Prof. HJ. Wester\, Department of Nuclear Medicine\, Technical U
 niversity Munich\, Germany
DTSTART:20070330T130000Z
DTEND:20070330T140000Z
UID:TALK6991@talks.cam.ac.uk
CONTACT:Vanessa Blake
DESCRIPTION:The availability of specific imaging probes is the "nuclear fu
 el" for\nmolecular imaging by Positron Emission Tomography (PET) and Singl
 e Photon\nEmission Tomography (SPECT). These two radiotracer based imaging
  modalities\nrepresent the prototype methods for non-invasive depiction an
 d\nquantification of biochemical processes\, allowing a functional\ncharac
 terization of biology in the living organism.  A variety of powerful\nradi
 olabeled probes -tracers- are already established in the routine\nclinical
  management of human disease and others are currently subject to\nclinical
  assessment. Emerging from investigations of the genomic and\nproteomic si
 gnatures of cancer cells\, an increasing number of promising\ntargets are 
 being identified\, including receptors\, enzymes\, transporters and\nantig
 ens. Corresponding probes for these newly-identified targets need to be\nd
 eveloped and transferred into the clinical setting. An overview of tracer\
 nconcepts\, target selection and development strategies for radiotracers i
 s\ngiven and the potential impact of µ-fluidic systems for routine tracer
 \nproduction is discussed.
LOCATION:Lecture Theatre 2\, Department of Chemical Engineering
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