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SUMMARY:Gene silencing in plant development and disease resistance: lesson
 s from tomato - Zhengming Wang\, Baulcombe Group
DTSTART:20170112T130000Z
DTEND:20170112T133000Z
UID:TALK69930@talks.cam.ac.uk
CONTACT:42122
DESCRIPTION:Gene silencing downregulates gene expression\, which can occur
  during either transcription (TGS) or post transcription (PTGS). TGS\, mai
 nly through epigenetic modifications of target genes\, plays an important 
 role in genome stability. However\, PTGS\, mainly through target mRNA clea
 vage or translation inhibition\, is important for gene regulation and anti
 viral defence. We have recently used CRISPR/Cas9 to create tomato mutants 
 of genes involved in TGS and maintenance of Histone3 lyscine9 di-methylati
 on (H3K9me2). Phenotyping and molecular analysis of these mutants reveal t
 hat H3K9me2 plays a crucial role in tomato development and reproduction. I
 n addition\, we identified a feedback regulatory loop of Dicer-like (DCL) 
 2 and miR6026\, which deepens our understanding of how antiviral PTGS resp
 onds to virus infection in tomato.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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