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SUMMARY:From the bush to the bench: a short-lived african fish reveals nov
 el aspects of the genetic control of aging - Alessandro Cellerino\, Scuola
  Normale Superiore\, Pisa\, Italy and Leibniz Institute on Aging\, Fritz L
 ipmann Institute\, Jena\, Germany
DTSTART:20170118T103000Z
DTEND:20170118T113000Z
UID:TALK70118@talks.cam.ac.uk
CONTACT:Priyanka Joshi
DESCRIPTION:African annual fishes from the genus Nothobranchius are small 
 teleosts that inhabit temporary water bodies subject to annual desiccation
  due to the alternation of the monsoon seasons and their natural lifespan 
 is of a few months. Nothobranchius furzeri is the vertebrate species with 
 the shortest lifespan recorded in captivity. Its short lifespan is coupled
  to rapid age-dependent functional decline and expression of cellular and 
 molecular changes comparable to those observed in other vertebrates\, incl
 uding humans. We report a high-quality draft of its genome and extensive s
 tudies of RNA-seq that analyzed genome-wide transcript regulation during a
 ging of this species. The analysis of these data provided novel insights i
 n the genetics of vertebrate aging: (i) we revealed that aging-related gen
 es tend to cluster in specific genomic regions\, (ii) we performed a longi
 tudinal analysis of gene expression and identified genes coding for comple
 x I of the respiratory chain as predictors of longevity\, (iii) we demonst
 rated that partial pharmacological inhinibition of complex I induces life-
 extension and rejuvenation of the transcriptome. (iv) we identified genes 
 under positive selection as a response to fast aging\, under those\, again
 \, respiratory chain was enriched (v) we identified miR-29 as an evolution
 ary-conserved miRNA that is regulated during aging in multiple species and
  tissues and (vi) we demonstrated that inhibition of miR-29 in vivo accele
 rates the expression of aging phenotypes.
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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