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SUMMARY:&quot\;Molecular regulation of cortical interneuron diversity and 
 plasticity&quot\; - Oscar Marin\, King's College London
DTSTART:20170227T163000Z
DTEND:20170227T180000Z
UID:TALK70208@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:Neural identity is thought to be established at or near the ti
 me at which neurons exit the cell cycle to become postmitotic cells\, and 
 is largely determined by intrinsic factors such as proneural genes and hom
 eodomain proteins. Once the identity of a neuron has been established\, it
  is generally accepted that its fate is maintained throughout life\, and w
 ill not change even after heterotopic transplantation. This contributes to
  maintaining a stable ‘ground state’ that defines their role in functi
 onal circuits. Consequently\, neural responses to environmental changes ar
 e thought to emerge through the function of neural circuits in which the i
 dentity of neurons remains stable. Based on these principles\, the search 
 for the mechanisms controlling the diversity of GABAergic interneurons in 
 the cerebral cortex has primarily focused on the analysis of transcription
 al programs in their progenitor cells. In this seminar\, I will describe h
 ow transcriptional programmes\, both during embryonic development and in t
 he postnatal brain\, regulate the identity of specific classes of cortical
  interneurons\, thereby contributing to the generation of neuronal diversi
 ty in the cerebral cortex.\n\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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