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SUMMARY:The architecture of muscle attachment sites. - Hannah Green -Brown
  Lab\, Gurdon Institute
DTSTART:20170118T173000Z
DTEND:20170118T193000Z
UID:TALK70238@talks.cam.ac.uk
CONTACT:Clara Sidor
DESCRIPTION:Integrins control cell adhesion to the extracellular matrix \n
 (ECM) by providing an indirect link between the ECM and the actin \ncytosk
 eleton. Integrin adhesions are consistently associated with a core \nof 60
  different proteins (integrin associated proteins\, IAPs) that \ncoordinat
 e integrin functions. It is unclear why integrin adhesions \nrequire so ma
 ny proteins\, but one possibility is that they divide the \nadhesion into 
 distinct functional layers. Focal adhesions have been  shown\nto be layere
 d\, but it is unknown whether similar layers exist in  stable\nintegrin ad
 hesions in tissues. We have identified similar layers  in the\nintegrin ad
 hesions of Drosophila indirect flight muscles (IFMs).\nWe were struck by t
 he similarity of these adhesions to the structure of  a\nhand and thus ter
 med the layers fingers\, palm and wrist. The fingers  are\nsimilar to laye
 rs seen in focal adhesions but the palm and wrist are \nconsiderably diffe
 rent. Distinct sets of IAPs are required to build the \nlayers: the finger
 s are built by FAK\, RSU1\, tensin and vinculin\, while the\npalm is built
  by vinculin and filamin.
LOCATION:Gurdon Institute Tea Room
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