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SUMMARY:Mitochondrial-ER interactions and dynamics in neurons - Victoria H
 ewitt - Whitworth Lab\, Mitochondrial Biology Unit
DTSTART:20170118T173000Z
DTEND:20170118T193000Z
UID:TALK70239@talks.cam.ac.uk
CONTACT:Clara Sidor
DESCRIPTION:Mitochondria and ER have highly dynamic\, intricate and\ninter
 acting morphologies. The contacts between these two organelles are\nvital 
 hubs of intracellular communication that influence the morphology of\nthe 
 mitochondria and mediate transfer of calcium and lipids. The\ncomponents o
 f the contact sites and associated regulatory proteins are\nslowly being i
 dentified but the biological relevance of these contacts for\nthe function
  of tissues or whole organisms is still very poorly\nunderstood.\nIn neuro
 ns the morphology of the mitochondria and ER are highly\nspecialised and v
 ary across the different subcellular neuronal\ncompartments. Alterations i
 n the dynamics and morphology of the ER and\nmitochondria in neurons are a
 ssociated with many neurodegenerative\ndiseases. I am using larval motor n
 eurons to explore the biological\nsignificance of the interplay of these t
 wo organelles. I will present the\nmethodology I am using to investigate t
 he dynamics of these organelles in\nvivo with an overview of my research i
 nto how modulation of tethering\,\nmitochondrial morphology and calcium si
 gnalling influence mitochondrial\ndynamics and transport in axons.
LOCATION:Gurdon Institute Tea Room
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