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SUMMARY: &quot\;Practical Applications of Analysing the Antibody Repertoir
 e&quot\; - Dr Rachael Bashford-Rogers\; Department of Medicine\, Universit
 y of Cambridge 
DTSTART:20170113T130000Z
DTEND:20170113T140000Z
UID:TALK70258@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Understanding the clonal dynamics of immune cells can be of gr
 eat clinical importance\, both for diagnosis and monitoring disease and th
 e success of therapy as well as for understanding the generation of therap
 eutic resistance. The advent of next-generation sequencing now allows us t
 o probe the genetic diversity of immune receptors in B-cell populations\, 
 which promises to revolutionise our understanding of adaptive immune respo
 nse. Having established methods for deep-sequencing B-cell RNA/DNA encodin
 g antibodies\, here I address:  \n\n- How have we used high-resolution cha
 racterisation to give insights into the B-cell response?\n- What are the a
 pplications of these new technologies?\n- Providing insight into immunity 
 in the context of health and disease\n- Further developments of methodolog
 y now enable the simultaneous probing of both antibody function and specif
 icity\, providing a highly sensitive and powerful tool for understanding d
 isease.\n
LOCATION:Babraham - The Brian Heap Seminar Room
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