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SUMMARY:Cellular responses to DNA damage:  molecular mechanisms and therap
 eutic applications - Steve Jackson (University of Cambridge)
DTSTART:20170123T133000Z
DTEND:20170123T143000Z
UID:TALK70267@talks.cam.ac.uk
CONTACT:Eric Rahrmann
DESCRIPTION:Dear Colleagues\, \n \nThe Cambridge Institute Scientists’ S
 ociety (CISS) would like to invite you all to our biannual seminar series 
 on 23 January 2016 at 13:30 in the CRUK CI Lecture Theatre\n \nOur guest l
 ecturer is: Prof. Steve Jackson FRS FMedSci\, Frederick James Quick Profes
 sor of Biology\, Member of the Biochemistry Department. Steve is also an A
 ssociate Faculty Member of the Wellcome Trust Sanger Institute.  He identi
 fied many DNA-damage-response (DDR) proteins\, established how they functi
 on and how they are in many cases strongly evolutionarily conserved\, and 
 helped define how their dysfunction yields cancer and other diseases. He h
 as received various national and international prizes\, and his publicatio
 ns have collectively been cited >53\,000 times (Google Scholar\;h-index 11
 5). It will be a fantastic talk and we hope to see you all there!!\n \nTal
 k title: \nCellular responses to DNA damage:  molecular mechanisms and the
 rapeutic applications\n \nResearch summary/interests:\nCharacterising the 
 cell biology of DNA-damage response (DDR) pathways to discover new therape
 utic strategies\, using yeast and mammalian cells in culture. They aim to 
 identify important DDR proteins\, and their functions\, regulation and rol
 es in diverse cellular events. They recently developed a new screening tec
 hnique to find enzymes that modify DDR protein activity\, focusing on the 
 many cellular proteins involved in ubiquitylation/deubiquitylation. They a
 re also exploring the concepts of synthetic lethality and synthetic viabil
 ity to identify novel therapeutic targets for a range of human diseases.
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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