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SUMMARY:Max Perutz Lecture- Antisense transcription and epigenetic switchi
 ng - Caroline Dean\, John Innes Centre\, Norwich
DTSTART:20170427T100000Z
DTEND:20170427T110000Z
UID:TALK70283@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:What quantitatively regulates gene expression? Non-coding tran
 scription and chromatin regulation are now seen as major factors regulatin
 g gene expression in most eukaryotic genomes. Through the study of how pla
 nts time developmental transitions\, we have discovered that Arabidopsis f
 loral repressor FLC is an excellent system in which to dissect how non-cod
 ing RNA and chromatin mechanisms regulate gene expression. FLC expression 
 is quantitatively modulated by an antisense-mediated chromatin mechanism t
 hat coordinately influences transcription initiation and elongation. Expre
 ssion is then epigenetically silenced through a cold-induced\, cis-based\,
  Polycomb switching mechanism. The talk will describe our latest understan
 ding of these conserved mechanisms and how they have been modulated during
  adaptation. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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