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SUMMARY:Charting the response to DNA damage - Dan Durocher\, University of
  Toronto\, Faculty of Medicine
DTSTART:20170515T100000Z
DTEND:20170515T110000Z
UID:TALK70285@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The orchestration of DNA repair is of fundamental importance t
 o the maintenance of genomic integrity and tumour suppression. DNA damage 
 must be detected in the context of the varied chromatin landscape\, its pr
 esence must be communicated throughout the cell to alter many ongoing proc
 esses\, and the machinery that will mend the lesion must be recruited to t
 he damage site. Our understanding of the pathways involved in the DNA dama
 ge response in human cells is often the result of pioneering studies in ge
 netically-tractable organisms or through the identification of gene mutati
 ons causing genome instability syndromes. With the advent of CRISPR/Cas9-b
 ased gene editing\, there is an opportunity to prospectively chart the res
 ponse to DNA damage in human cells. During my presentation\, I will presen
 t our efforts to map the genetic networks that govern the DNA damage respo
 nse and will particularly discuss our work aimed at mapping the genetic ar
 chitecture of the response to PARP inhibitors. Our work revealed new types
  of genetic vulnerabilities to PARP inhibition and in particular\, I will 
 discuss a type DNA lesion that could act as the elusive inhibited-PARP “
 trap”..
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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