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SUMMARY:Time\, space and disorder in the expanding protein universe - Chri
 s Taylor (CRUK) &amp\; David Minde (Cambridge Centre for Proteomics)
DTSTART:20170308T183000Z
DTEND:20170308T200000Z
UID:TALK70303@talks.cam.ac.uk
CONTACT:Dr Caitlin Hitchcock
DESCRIPTION:Proteins are highly dynamic entities. Their myriad functions r
 equire specific structures\, but proteins’ dynamic nature ranges all the
  way from the local mobility of their amino acid constituents to mobility 
 within and well beyond single cells. \n\nA truly comprehensive view of the
  dynamic structural proteome includes: (1) alternative sequences\, (2) alt
 ernative conformations\, (3) alternative interactions with a range of biom
 olecules\, (4) cellular localisations\, (5) alternative behaviours in diff
 erent cell types. While these aspects have traditionally been explored one
  protein at a time\, we explore recently emerging global approaches that a
 ccelerate comprehensive insights into these facets of the dynamic nature o
 f protein structure. \n\nWe use chemical crosslinking with a gas-phase cle
 avable linker and enzymatic biotin-labeling to gain complementary insights
  into protein complexes and cellular architectures
LOCATION: Postdoc Centre\, Biomedical Campus\, Bay 13\, Hills Road\, Cambr
 idge CB2 0SP
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