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SUMMARY:Signaling pathways to resilience or dysfunction in the brain - Pro
 fessor Giles Hardingham\, University of Edinburgh
DTSTART:20170209T160000Z
DTEND:20170209T170000Z
UID:TALK70434@talks.cam.ac.uk
CONTACT:Maria Schacker
DESCRIPTION:RESEARCH SUMMARY: In central neurons\, Ca2+ entry through the 
 NMDA-type glutamate receptor (NMDAR) is a major source of synaptically-evo
 ked Ca2+ transients and directly affects neuronal survival/death: while to
 o much NMDAR activity is harmful\, so is too little (Hardingham and Bading
 \, 2003\; Papadia and Hardingham\, 2007). Understanding the mechanisms beh
 ind this dichotomous signalling is an area of molecular neuroscience with 
 direct clinical implications. The research of my group focuses on understa
 nding the signalling events that are triggered by NMDAR activity\, and the
 ir impact on neuronal survival and death\, and comprise three main themes.
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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